Hydrochloric Acid → HCID 66652527, compound

HRID 2362887Notes

Reaction equation

HRID 2362887 reaction equation
[NH2:1][C:2](=[O:38])[CH2:3][O:4][C:5]([C:7]1[CH:8]=[C:9]([CH:35]=[CH:36][CH:37]=1)[CH2:10][N:11]1[C:15](=[O:16])[C:14]2([CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]2)[N:13]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:12]1)=[O:6].Cl>O1CCOCC1>[O:16]=[C:15]1[C:14]2([CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[N:13]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:12][N:11]1[CH2:10][C:9]1[CH:8]=[C:7]([CH:37]=[CH:36][CH:35]=1)[C:5]([O:4][CH2:3][C:2]([NH2:1])=[O:38])=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046811HCID 58046811, compound

Product 1

HCID 66652527HCID 66652527, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(3-((2-amino-2-oxoethoxy)carbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.22 g, 0.42 mmol) was added 4M solution of HCl in dioxane (4 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain 2-amino-2-oxoethyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-395cbb337bdb4dde9b7317f5a2ff88a8
Source dataset
uspto-grants-2014_04
Patent number
US08691836B2

Reaction notes

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