Hydrochloric Acid → HCID 66652119, compound

HRID 2362929Notes

Reaction equation

HRID 2362929 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:35]=[CH:36][CH:37]=1)[CH2:8][N:9]1[C:13](=[O:14])[C:12]2([CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)[N:11]([C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=2)[CH2:10]1)=[O:4].Cl>O1CCOCC1>[CH3:34][O:33][C:30]1[CH:29]=[CH:28][C:27]([N:11]2[C:12]3([CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[C:13](=[O:14])[N:9]([CH2:8][C:7]3[CH:6]=[C:5]([CH:37]=[CH:36][CH:35]=3)[C:3]([O:2][CH3:1])=[O:4])[CH2:10]2)=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046760HCID 58046760, compound

Product 1

HCID 66652119HCID 66652119, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(3-(methoxycarbonyl)benzyl)-1-(4-methoxyphenyl)-4-oxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.47 g, 0.92 mmol) was added 4M solution of HCl in dioxane (10 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain methyl 3-((1-(4-methoxyphenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-5ac72a7812f1403da705889a17aeda39
Source dataset
uspto-grants-2014_04
Patent number
US08691836B2

Reaction notes

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