Diethyl Ether → 1H-Purine-2,6-dione, 3,7-dihydro-3-(cyclohexylmethyl)-

HRID 236300Notes

Reaction equation

HRID 236300 reaction equation
[NH2:1][C:2]1[C:3](=[O:17])[NH:4][C:5](=[O:16])[N:6]([CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[C:7]=1[NH2:8].[CH:18](Cl)(Cl)Cl.CCOCC>C(O)=O>[CH:10]1([CH2:9][N:6]2[C:7]3[N:8]=[CH:18][NH:1][C:2]=3[C:3](=[O:17])[NH:4][C:5]2=[O:16])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6212ChloroformHCID 131714386HCID 131714386, compound

Product 1

HCID 30589991H-Purine-2,6-dione, 3,7-dihydro-3-(cyclohexylmethyl)-

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2 g of 5,6-diamino-1-cyclohexylmethyl-2,4-(1H,3H)-pyrimidine dione (XXII) was refluxed in 10 ml of formic acid for 1 h. 5 ml of chloroform was added and ether was then added slowly. The received crystals were filtered off. Yield 2.1 g (XXIII). The amide (XXIII) was refluxed in 15 ml of 2N NaOH for 1 hour and then neutralized with 5N HCl.

Workup

  1. filtrationThe received crystals were filtered off
  2. temperatureThe amide (XXIII) was refluxed in 15 ml of 2N NaOH for 1 hour

Sources & evidence

ORD record
ord-fa4decf5ca3a4d4e919a7d6d18165f3b
Source dataset
uspto-grants-1987_02
Patent number
US04644001

Reaction notes

Loading…