Acetic Acid → HCID 20217052, compound

HRID 236307Notes

Reaction equation

HRID 236307 reaction equation
[CH:1]1([N:5]2[C:10]([NH2:11])=[C:9]([NH2:12])[C:8](=[O:13])[NH:7][C:6]2=[O:14])[CH2:4][CH2:3][CH2:2]1.[C:15](O)(=O)[CH3:16]>>[CH:1]1([N:5]2[C:10]3[N:11]=[C:15]([CH3:16])[NH:12][C:9]=3[C:8](=[O:13])[NH:7][C:6]2=[O:14])[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 54485518HCID 54485518, compound

Product 1

HCID 20217052HCID 20217052, compound

Procedure

A solution of 2.2 g of 1-cyclobutyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione (X) in 10 ml of acetic acid was refluxed for 2 hours. The solution was evaporated. The received oil was refluxed in 30 ml of 5N NaOH for 1 hour and then neutralized with 5N HCl. The crystals were filtered off and recrystallized from 100 ml ethanol.

Workup

  1. customThe solution was evaporated
  2. temperatureThe received oil was refluxed in 30 ml of 5N NaOH for 1 hour
  3. filtrationThe crystals were filtered off
  4. customrecrystallized from 100 ml ethanol

Sources & evidence

ORD record
ord-98325eadf8054070ae3b6d33d054799b
Source dataset
uspto-grants-1987_02
Patent number
US04644001

Reaction notes

Loading…