Lithium Hydroxide → HCID 58319216, compound

HRID 2363087Notes

Reaction equation

HRID 2363087 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[S:9][CH:10]=1)=[O:5])C.[Li+].[OH-]>>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([CH2:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)=[CH:13][CH:14]=1)([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 58319272HCID 58319272, compound

Product 1

HCID 58319216HCID 58319216, compound

Procedure

2-(4-tert-Butylbenzyl)thiazole-4-carboxylic acid ethyl ester was hydrolysized with 1M LiOH (5 ml). The reaction solvent was removed in vacuo. The residue was diluted with EtOAc and H2O and the aqueous layer was extracted with EtOAc. The combined organic layer was washed with brine, dried over MgSO4 and then concentrated in vacuo.

Workup

  1. customThe reaction solvent was removed in vacuo
  2. additionThe residue was diluted with EtOAc and H2O
  3. extractionthe aqueous layer was extracted with EtOAc
  4. washThe combined organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-3937f935990d4bfc9c1e93157c128713
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

Loading…