HCID 16110499, compound → HCID 67237736, compound

HRID 2363110Notes

Reaction equation

HRID 2363110 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:16][C:17]([C:19]2[N:20]=[C:21](Cl)[O:22][CH:23]=2)=[O:18])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10].[CH2:25]([C:28]1[CH:33]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:31]=[CH:30][C:29]=1[OH:38])[CH2:26][CH3:27]>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:16][C:17]([C:19]2[N:20]=[C:21]([O:38][C:29]3[CH:30]=[CH:31][C:32]([C:34]([F:35])([F:36])[F:37])=[CH:33][C:28]=3[CH2:25][CH2:26][CH3:27])[O:22][CH:23]=2)=[O:18])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 16110499HCID 16110499, compoundHCID 671108872-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide

Product 1

HCID 67237736HCID 67237736, compoundYield 56.2%

Procedure

2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (50 mg, 0.13 mmol) was reacted with 2-propyl-4-trifluoromethylphenol (37 mg, 0.18 mmol) to give the title compound (40 mg, 55%) after purification by flash chromatography on silica gel (gradient 12% to 100% EtOAc in n-hexane).

Sources & evidence

ORD record
ord-b82efe7dc53c46e6a8cfe0157a70267b
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

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