HCID 67111152, compound → HCID 58319264, compound

HRID 2363116Notes

Reaction equation

HRID 2363116 reaction equation
[CH:1](=[C:3]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([OH:12])[C:6]=2[CH2:5][CH2:4]1)[CH3:2].[H][H]>CO.CCOC(C)=O.[Pd]>[CH2:1]([CH:3]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([OH:12])[C:6]=2[CH2:5][CH2:4]1)[CH3:2]

Participants

6

Reactant 2

HCID 67111152HCID 67111152, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58319264HCID 58319264, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1-ethylidene-indan-4-ol (37 mg, 0.23 mmol) and 10% Pd/C (12 mg, 10% weight) in methanol (4 ml) was hydrogenated under 50 psi hydrogen atmosphere for 1 hour. The mixture was dissolved in EtOAc, filtered through a celite pad. The filtrate was concentrated under reduced pressure, and dried to 1-ethyl-indan-4-ol (36 g, 97%)

Workup

  1. filtrationfiltered through a celite pad
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. dry with materialdried to 1-ethyl-indan-4-ol (36 g, 97%)

Sources & evidence

ORD record
ord-6c45bc63d65a4b7281383682f2bba710
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

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