Hydrochloric Acid → HCID 178478604, compound

HRID 236312Notes

Reaction equation

HRID 236312 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]2[N:13]=[C:14]([NH:17][C:18]([NH2:20])=[NH:19])[S:15][CH:16]=2)=[N:5]S(=O)[N:3]=1.[ClH:22]>CO>[ClH:22].[ClH:22].[ClH:22].[NH:17]([C:14]1[S:15][CH:16]=[C:12]([CH2:11][S:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])[N:13]=1)[C:18]([NH2:20])=[NH:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178512710HCID 178512710, compound

Product 1

HCID 178478604HCID 178478604, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-amino-4-{2-[(2-guanidinothiazol-4-yl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide (5.25 g; 13.7 mmoles) [prepared according to published United Kingdom patent application No. 2,067,987] in 105 ml of methanol was treated with 80 ml of concentrated HCl to give an immediate yellow solution. After stirring at ambient temperature for 4.25 hours, the solution was concentrated to near dryness and the residue was triturated with acetone, filtered and dried to give the title compound.

Workup

  1. customprepared
  2. customto give an immediate yellow solution
  3. concentrationthe solution was concentrated
  4. customthe residue was triturated with acetone
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-175ef41eeac84369ba5d32d565ea1a32
Source dataset
uspto-grants-1987_02
Patent number
US04644006

Reaction notes

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