HCID 19854149, compound → HCID 58319191, compound

HRID 2363129Notes

Reaction equation

HRID 2363129 reaction equation
[CH2:1]([C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][CH:7]=[CH:6][C:5]=1[OH:14])[CH:2]=[CH2:3].[H][H]>CO.CCOC(C)=O.[Pd]>[CH2:1]([C:4]1[C:9]([C:10]([F:12])([F:13])[F:11])=[CH:8][CH:7]=[CH:6][C:5]=1[OH:14])[CH2:2][CH3:3]

Participants

6

Reactant 2

HCID 19854149HCID 19854149, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58319191HCID 58319191, compoundYield 87%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 2-allyl-3-trifluoromethyl-phenol and 10% Pd/C (20 mg) in methanol (4 ml) was hydrogenated under 50 psi hydrogen atmosphere for 1 hour. The mixture was dissolved in EtOAc, filtered through a celite pad. The filtrate was concentrated under reduced pressure, and dried to give 2-propyl-3-trifluoromethyl-phenol (53 mg, 87%).

Workup

  1. filtrationfiltered through a celite pad
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-bec87235b5f644b3a3db8a3a52a42bce
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

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