HCID 58319168, compound → HCID 58319215, compound

HRID 2363151Notes

Reaction equation

HRID 2363151 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([OH:12])[C:6]=2[CH2:5][CH:4]=1.[H][H]>CO.CCOC(C)=O.[Pd]>[F:1][C:2]([F:13])([F:14])[CH:3]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([OH:12])[C:6]=2[CH2:5][CH2:4]1

Participants

6

Reactant 2

HCID 58319168HCID 58319168, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58319215HCID 58319215, compoundYield 97%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1-trifluoromethyl-3H-inden-4-ol (70 mg, 0.349) and 10% Pd/C (20 mg) in methanol (2 ml) was hydrogenated under 50 psi hydrogen atmosphere for 3 hours. The mixture was dissolved in EtOAc, filtered through a celite pad. The filtrate was concentrated tinder reduced pressure, and dried to give 1-trifluoromethyl-indan-4-ol (68 mg, 97%).

Workup

  1. filtrationfiltered through a celite pad
  2. concentrationThe filtrate was concentrated tinder reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-f5f8901936b5429c8e79cc8171987683
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

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