HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Phosphate, Tribasic → 1-Chloro-3,5-dicyclopropylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Tricyclohexylphosphine | HCID 75806 | — |
| Reactant | 1,3-Dibromo-5-chlorobenzene | HCID 84676 | — |
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | 1-Chloro-3,5-dicyclopropylbenzene | HCID 67111883 | 477.5% |
Reaction Steps
1-Chloro-3,5-dibromobenzene (2.70 g, 10.0 mmol) and cyclopropylboronic acid (1.72 g, 20 mmol) were reacted using K3PO4 (14.9 g, 70 mmol), tricyclohexylphosphine (56 mg, 2.0 mmol), Pd(OAc)2 (288 mg, 1.0 mmol) as described above to give 1-chloro-3,5-dicyclopropyl-benzene (1.84 g, 96%) after purification by flash chromatography on silica gel (% EtOAc in hexane=2%˜10%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691855B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-4bbce9305f8c4579ae598837a7ca25ea |
| Source note | uspto-grants-2014_04 |