Sulfamide → HCID 11379214, compound

HRID 2363228Notes

Reaction equation

HRID 2363228 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH2:11].[S:12](N)([NH2:15])(=[O:14])=[O:13]>O1CCOCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH:11][S:12]([NH2:15])(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 82267SulfamideHCID 573560261-(2H-1,3-Benzodioxol-2-yl)methanamine

Product 1

HCID 11379214HCID 11379214, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

C-Benzo[1,3]dioxol-2-yl-methylamine (2.94 g, 19.4 mmol) and sulfamide (3.74 g, 38.9 mmol) were combined in dry dioxane (50 mL) and the solution was heated to reflux overnight. The reaction was concentrated and the residue was chromatographed (2% to 10% acetone in dichloromethane) to yield the title compound as a white solid.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux overnight
  3. concentrationThe reaction was concentrated
  4. customthe residue was chromatographed (2% to 10% acetone in dichloromethane)

Sources & evidence

ORD record
ord-d3f7ce379d714424a6c82a0715d59056
Source dataset
uspto-grants-2014_04
Patent number
US08691867B2

Reaction notes

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