反应详情

The oily amine (1.63 g, 10 mmol) and sulfamide (1.92 g, 20 mmol) were combined in dioxane (50 mL) and brought to reflux for 2 h. The solution was cooled and evaporated in vacuo to yield an oil, which was purified via column chromatography (DCM:Methanol 10:1) to yield a white solid. The solid was recrystallized from ethyl acetate/hexane to yield chroman-2-ylmethylsulfamide as a white solid.

1. temperatureto reflux for 2 h
2. temperatureThe solution was cooled
3. customevaporated in vacuo
4. customto yield an oil, which
5. customwas purified via column chromatography (DCM:Methanol 10:1)
6. customto yield a white solid
7. customThe solid was recrystallized from ethyl acetate/hexane