Citric Acid → HCID 86662969, Verbindung

HRID 2363240Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2363240
[CH:1]#[C:2][CH2:3][NH:4][C@H:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6]1.[C:14]([OH:26])(=[O:25])[CH2:15][C:16]([CH2:21][C:22]([OH:24])=[O:23])([C:18]([OH:20])=[O:19])[OH:17]>>[CH:1]#[C:2][CH2:3][NH:4][C@H:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6]1.[C:14]([O-:26])(=[O:25])[CH2:15][C:16]([CH2:21][C:22]([O-:24])=[O:23])([C:18]([O-:20])=[O:19])[OH:17]

Komponenten

3

Edukt 2

HCID 311Citric AcidHCID 3052776Rasagiline

Produkt 1

HCID 86662969HCID 86662969, Verbindung

Versuchsvorschrift

The experiments conducted in this example are listed below in Table 3. In each of the experiments, rasagiline free base, excipient, and citric acid were combined and mixed. A solid dispersion was prepared from the mixture by dry milling, wet milling, or cryo-grinding the mixture at conditions listed in Table 3 below.

Aufarbeitung

  1. additionmixed
  2. customA solid dispersion was prepared from the mixture
  3. customby dry milling, wet milling
  4. customcryo-grinding the mixture at conditions

Quellen und Nachweise

ORD-Eintrag
ord-6b943e28f8ad4e4a838132c3b71aa459
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08691872B2

Notizen zur Reaktion

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