3-Ethoxy-1-propanol → HCID 13828790, compound

HRID 2363251Notes

Reaction equation

HRID 2363251 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][CH2:6][OH:7])[CH3:2].[C:8](Cl)(=[O:12])[C:9]([Cl:11])=[O:10]>C(Cl)Cl>[CH2:1]([O:3][CH2:4][CH2:5][CH2:6][O:7][C:8](=[O:12])[C:9]([Cl:11])=[O:10])[CH3:2]

Participants

4

Reactant 2

HCID 81093-Ethoxy-1-propanolHCID 65578Oxalyl chloride

Product 1

HCID 13828790HCID 13828790, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 3-ethoxypropan-1-ol (404 mg, 3.9 mmol) in DCM (total volume: 0.5 mL) was added to a solution of oxalyl chloride (0.5 mL, 5.8 mmol) in DCM (total volume 1.0 mL) at 0° C. and the resulting mixture was stirred at room temperature for 30 minutes. The mixture was concentrated in vacuo and the resulting residue was dissolved in DCM (3.9 mL) to yield a 1.0M solution in DCM.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. dissolutionthe resulting residue was dissolved in DCM (3.9 mL)

Sources & evidence

ORD record
ord-96757839c1fd4275aa427a5b78cf34a3
Source dataset
uspto-grants-2014_04
Patent number
US08691868B2

Reaction notes

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