Phenoxyethanol → HCID 19612335, compound

HRID 2363252Notes

Reaction equation

HRID 2363252 reaction equation
[O:1]([CH2:8][CH2:9][OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:11](Cl)(=[O:15])[C:12]([Cl:14])=[O:13]>C(Cl)Cl>[O:1]([CH2:8][CH2:9][O:10][C:11](=[O:15])[C:12]([Cl:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 31236PhenoxyethanolHCID 65578Oxalyl chloride

Product 1

HCID 19612335HCID 19612335, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 2-phenoxyethanol (536 mg, 3.9 mmol) in DCM (total volume: 0.5 mL) was added to a solution of oxalyl chloride (0.5 mL, 5.8 mmol) in DCM (total volume 1.0 mL) at 0° C. and the resulting mixture was stirred at room temperature for 30 minutes. The mixture was concentrated in vacuo and the resulting residue was dissolved in DCM (3.9 mL) to yield a 1.0M solution in DCM.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. dissolutionthe resulting residue was dissolved in DCM (3.9 mL)

Sources & evidence

ORD record
ord-4c54960e6f48410d838a0d3d826a6234
Source dataset
uspto-grants-2014_04
Patent number
US08691868B2

Reaction notes

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