HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol hydrochloride → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol hydrochloride | HCID 21887872 | — |
| Reactant | (R)-3-[N-(4-Bromobenzyl)-N'-t-butoxycarbonylhydrazino]-2-hydroxypropionic acid methyl ester | HCID 67972599 | — |
| Product | Hydrochloric Acid | HCID 313 | 663.5% |
| Product | 3-[N-(4-Bromobenzyl)hydrazino]-2-hydroxypropionic Acid Ethyl Ester | HCID 86682256 | — |
Reaction Steps
A solution of (R)-3-[N-(4-bromobenzyl)-N′-t-butoxycarbonylhydrazino]-2-hydroxypropionic acid methyl ester (25 g, 62 mmol) in EtOH/HCl (310 mL, 1.0 M, 0.3 mol) was stirred overnight. The mixture was concentrated and the reside was washed with EtOAc (120 mL) and filtered to yield the title compound as a white solid HCl salt (15 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691868B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-4db0bc86997f407e9d6a17966ee41e4c |
| Source note | uspto-grants-2014_04 |