Ethanol hydrochloride → Hydrochloric Acid

HRID 2363258Notes

Reaction equation

HRID 2363258 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([OH:23])[CH2:5][N:6]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=1)[NH:7]C(OC(C)(C)C)=O.[CH3:25]CO.[ClH:28]>>[CH2:1]([O:2][C:3](=[O:24])[CH:4]([OH:23])[CH2:5][N:6]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=1)[NH2:7])[CH3:25].[ClH:28]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 67972599HCID 67972599, compound

Product 2

HCID 313Hydrochloric AcidYield 663.5%HCID 866822563-[N-(4-Bromobenzyl)hydrazino]-2-hydroxypropionic Acid Ethyl Ester

Procedure

A solution of (R)-3-[N-(4-bromobenzyl)-N′-t-butoxycarbonylhydrazino]-2-hydroxypropionic acid methyl ester (25 g, 62 mmol) in EtOH/HCl (310 mL, 1.0 M, 0.3 mol) was stirred overnight. The mixture was concentrated and the reside was washed with EtOAc (120 mL) and filtered to yield the title compound as a white solid HCl salt (15 g).

Workup

  1. concentrationThe mixture was concentrated
  2. washthe reside was washed with EtOAc (120 mL)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-4db0bc86997f407e9d6a17966ee41e4c
Source dataset
uspto-grants-2014_04
Patent number
US08691868B2

Reaction notes

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