Hydroxyamine hydrochloride → HCID 86738404, compound

HRID 236326Notes

Reaction equation

HRID 236326 reaction equation
Cl.[NH2:2][OH:3].C([O-])(=O)C.[Na+].[CH2:9]([N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]2[CH:21]=[C:22]([CH:24]=O)[N:23]=[C:13]2[C:12]1=[O:26])[CH3:10]>O.C(O)C>[CH2:9]([N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]2[CH:21]=[C:22]([CH:24]=[N:2][OH:3])[N:23]=[C:13]2[C:12]1=[O:26])[CH3:10]

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 13770484HCID 13770484, compound

Product 1

HCID 86738404HCID 86738404, compoundYield 81.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

A solution of 0.2 g of hydroxylamine hydrochloride and 0.25 g of sodium acetate in 2 ml of water was added to a suspension of 0.5 g of the product of Example 22 in 10 ml of ethanol and the mixture was stirred at 90° C. for 4 hours and was then filtered. The recovered product was washed with water and dried in vacuo to obtain 0.435 g of pure 4,5-dihydro-5-ethyl-4-oxo-imidazo-[1,2-a]-quinoxaline-2-carboxaldehyde oxime melting at 286°-288° C.

Workup

  1. filtrationwas then filtered
  2. washThe recovered product was washed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-c796ddab14064e7cae3ca80af42845f9
Source dataset
uspto-grants-1987_02
Patent number
US04644002

Reaction notes

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