Water → HCID 86738405, compound

HRID 236329Notes

Reaction equation

HRID 236329 reaction equation
Cl.[NH2:2][OH:3].C([O-])(=O)C.[Na+].[CH2:9]([N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]2[CH:21]=[C:22]([CH:24]=O)[CH:23]=[C:13]2[C:12]1=[O:26])[CH3:10].O>C(O)C>[CH2:9]([N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]2[CH:21]=[C:22]([CH:24]=[N:2][OH:3])[CH:23]=[C:13]2[C:12]1=[O:26])[CH3:10]

Participants

6

Reactant 4

HCID 962WaterHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 13770488HCID 13770488, compound

Product 1

HCID 86738405HCID 86738405, compoundYield 80.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.5 g (21.6 mmole) of hydroxylamine hydrochloride, 2 g (24.4 mmole) of sodium acetate, 3.4 g (14.1 mmole) of the product of Example 25, 20 ml of water and 40 ml of ethanol was warmed on a water bath for one hour and the mixture was evaporated to a volume of 20 ml. The mixture was filtered and the recovered product was rinsed with water and dried over P2O5 under vacuum to obtain 2.9 g of 4,5-dihydro-5-ethyl-4-oxopyrrolo-[1,2-a]-quinoxaline-2-carboxaldehyde oxime in the form of colorless needles melting at 262°-264° C.

Workup

  1. temperaturewas warmed on a water bath for one hour
  2. customthe mixture was evaporated to a volume of 20 ml
  3. filtrationThe mixture was filtered
  4. washthe recovered product was rinsed with water
  5. dry with materialdried over P2O5 under vacuum

Sources & evidence

ORD record
ord-cfa50710953b45ff92155fcc15145af9
Source dataset
uspto-grants-1987_02
Patent number
US04644002

Reaction notes

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