Hydrochloric Acid → HCID 20217058, compound

HRID 236333Notes

Reaction equation

HRID 236333 reaction equation
[ClH:1].[OH:2][CH2:3][C:4]1[N:5]=[C:6]2[C:15](=[O:16])[N:14]([CH2:17][CH3:18])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]2[CH:19]=1>CO>[ClH:1].[OH:2][CH2:3][C:4]1[N:5]=[C:6]2[C:15](=[O:16])[N:14]([CH2:17][CH3:18])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]2[CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13770483HCID 13770483, compound

Product 1

HCID 20217058HCID 20217058, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

1.0 ml of concentrated hydrochloric acid was added to a suspension of 2.0 g of 2-hydroxymethyl-5-ethyl-imidazo-[1,2-a]-quinoxaline-4(5H)-one in 40 ml of hot methanol and the solution was filtered hot. The filtrate was extracted with 20 ml of ethyl acetate and the organic phase was cooled to 0° C. and filtered to obtain 2.0 g of 2-hydroxymethyl-5-ethylimidazo-[1,2-a]-quinoxaline-4(5H)-one hydrochloride in the form of colorless crystals melting at 224°-226° C.

Workup

  1. filtrationthe solution was filtered hot
  2. extractionThe filtrate was extracted with 20 ml of ethyl acetate
  3. filtrationfiltered

Sources & evidence

ORD record
ord-fd1dd664249c47eab9651e06ea01706f
Source dataset
uspto-grants-1987_02
Patent number
US04644002

Reaction notes

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