HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → beta-Oxo-alpha-(3-trifluoromethylphenylcarbamoyl)-beta-(2-pyrrolyl)-propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(Trifluoromethyl)phenyl isocyanate | HCID 9483 | — |
| Reactant | 3-oxo-3-(1H-pyrrol-2-yl)propanenitrile | HCID 11194355 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | beta-Oxo-alpha-(3-trifluoromethylphenylcarbamoyl)-beta-(2-pyrrolyl)-propionitrile | HCID 13370092 | — |
Reaction Steps
Reaction of 2.0 g of 2-pyrroloylacetonitrile with 3.0 g of 3-(trifluoromethyl)-phenyl isocyanate in the presence of 1.8 g of Et3N in 25 ml of glyme similarly to the previous examples and recrystallization of the crude product from methanol gives β-oxo-α-(3-trifluoromethylphenylcarbamoyl)-β-(2-pyrrolyl)-propionitrile, m.p. 210°-212°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04644010 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-bd1866ce95df49028301bf91ddee6b32 |
| Source note | uspto-grants-1987_02 |