Methanol → beta-Oxo-alpha-(3-trifluoromethylphenylcarbamoyl)-beta-(2-pyrrolyl)-propionitrile
Reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH2:8][C:9]#[N:10])=[O:7].[F:11][C:12]([F:23])([F:22])[C:13]1[CH:14]=[C:15]([N:19]=[C:20]=[O:21])[CH:16]=[CH:17][CH:18]=1.CCN(CC)CC.CO>C(COC)OC>[O:7]=[C:6]([C:2]1[NH:1][CH:5]=[CH:4][CH:3]=1)[CH:8]([C:20](=[O:21])[NH:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([C:12]([F:11])([F:23])[F:22])[CH:14]=1)[C:9]#[N:10]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Reaction of 2.0 g of 2-pyrroloylacetonitrile with 3.0 g of 3-(trifluoromethyl)-phenyl isocyanate in the presence of 1.8 g of Et3N in 25 ml of glyme similarly to the previous examples and recrystallization of the crude product from methanol gives β-oxo-α-(3-trifluoromethylphenylcarbamoyl)-β-(2-pyrrolyl)-propionitrile, m.p. 210°-212°.
Sources & evidence
- ORD record
- ord-bd1866ce95df49028301bf91ddee6b32
- Source dataset
- uspto-grants-1987_02
- Patent number
- US04644010
Reaction notes
Loading…