Hydrochloric Acid → HCID 20189446, compound

HRID 236358Notes

Reaction equation

HRID 236358 reaction equation
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][CH2:13][C:14]([O:16]C)=[O:15])=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:18])[CH3:2].[OH-].[Na+].Cl>CO>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:18])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20189481HCID 20189481, compound

Product 1

HCID 20189446HCID 20189446, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 12.9 g. (52.2 mmoles) of 1-ethyl-5-(2-carbomethoxyethyl)oxindole in 53 ml. of methanol was added 112.5 ml. of 1N sodium hydroxide solution. After stirring for 1 hour the reaction mixture was acidified by the addition of 165 ml. of 1N hydrochloric acid. The precipitated product was filtered and dried, 11.39 g. (93% yield).

Workup

  1. additionwas acidified by the addition of 165 ml
  2. filtrationThe precipitated product was filtered
  3. customdried

Sources & evidence

ORD record
ord-f3f6d30e33a44daa9cfa2ca790b3334c
Source dataset
uspto-grants-1987_02
Patent number
US04644005

Reaction notes

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