反应详情

230 mg of 6-iodo-N-phenylimidazo[1,2-a]pyridine-2-carboxamide (Intermediate 2), 690 mg of 2-tributylstannylpyridine, 120 mg of tetrakis(triphenylphosphine)palladium and 4 mL of N,N-dimethylformamide are placed in a microwave tube. The reaction mixture is heated for 5 minutes in a microwave machine set at 100° C., and then for 5 minutes at 150° C. and concentrated to dryness. The residue is chromatographed on a silica cartridge, eluting with a mixture of dichloromethane and ethyl acetate. The fractions containing the expected product are combined and evaporated to dryness under reduced pressure to give 56 mg of N-phenyl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide in the form of a white solid.

1. temperatureThe reaction mixture is heated for 5 minutes in a microwave machine
2. customset at 100° C.
3. concentrationconcentrated to dryness
4. customThe residue is chromatographed on a silica cartridge
5. washeluting with a mixture of dichloromethane and ethyl acetate
6. additionThe fractions containing the expected product
7. customevaporated to dryness under reduced pressure