反应详情

163 mg of 6-trimethylstannyl-N-phenylimidazo[1,2-a]pyridine-2-carboxamide (Intermediate 4), 310 mg of (5-bromopyrid-3-yl)methanol, 66 mg of tetrakis(triphenylphosphine)-palladium and 4 mL of N,N-dimethylformamide are placed in a microwave tube. The reaction mixture is heated for 20 minutes in a microwave machine set at 150° C. and concentrated to dryness. The residue is chromatographed on a silica cartridge, eluting with dichloromethane. The fractions containing the expected product are combined and evaporated to dryness under reduced pressure to give 61 mg of 6-[5-(hydroxymethyl)pyrid-3-yl]-N-phenylimidazo[1,2-a]pyridine-2-carboxamide in the form of a white solid.

1. temperatureThe reaction mixture is heated for 20 minutes in a microwave machine
2. customset at 150° C.
3. concentrationconcentrated to dryness
4. customThe residue is chromatographed on a silica cartridge
5. washeluting with dichloromethane
6. additionThe fractions containing the expected product
7. customevaporated to dryness under reduced pressure