Hydrochloric Acid → HCID 68779865, compound

HRID 2363697Notes

Reaction equation

HRID 2363697 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:10]=[CH:11][C:12]3[N:13]([CH:15]=[C:16]([C:18]([NH:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:19])[N:17]=3)[CH:14]=2)[CH:4]=1.[ClH:27]>CO>[ClH:27].[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:10]=[CH:11][C:12]3[N:13]([CH:15]=[C:16]([C:18]([NH:20][C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)=[O:19])[N:17]=3)[CH:14]=2)[CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68778309HCID 68778309, compound

Product 1

HCID 68779865HCID 68779865, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 117 mg of 6-[4-(hydroxymethyl)pyrid-2-yl]-N-phenylimidazo[1,2-a]pyridine-2-carboxamide in 2 mL of methanol is treated with 0.68 mL of aqueous 0.5 N hydrochloric acid solution. The mixture is stirred for 16 hours at room temperature and then evaporated to dryness under reduced pressure. The solid obtained is triturated in methanol, filtered off and dried to give 91 mg of 6-[4-(hydroxymethyl)pyrid-2-yl]-N-phenylimidazo[1,2-a]pyridine-2-carboxamide hydrochloride (1:1).

Workup

  1. customevaporated to dryness under reduced pressure
  2. customThe solid obtained
  3. customis triturated in methanol
  4. filtrationfiltered off
  5. customdried

Sources & evidence

ORD record
ord-5c873855de0945efa1f8ee4d18566ae6
Source dataset
uspto-grants-2014_04
Patent number
US08691990B2

Reaction notes

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