反应详情

温度

100 °C

To a mixture of 27.3 g. (19.9 mmoles) of 2-thenoyl chloride, 30 ml. of nitrobenzene and 32.95 g. of aluminum chloride was gradually added 10 g. (62 mmoles) of 1-ethyloxindole, and the resulting reaction mixture heated at 100° C. for 75 minutes. The reaction was cooled to room temperature and poured into 2 l. of ice and water. The product was extracted with methylene chloride and the dried extract concentrated to dryness, 11.05 g. The product was recrystallized from methylene chloride-hexane, 8.03 g. (47.7% yield)m, m.p. 158°-160° C.

1. additionTo a mixture of 27.3 g
2. temperatureThe reaction was cooled to room temperature
3. additionpoured into 2 l
4. extractionThe product was extracted with methylene chloride
5. extractionthe dried extract
6. concentrationconcentrated to dryness, 11.05 g
7. customThe product was recrystallized from methylene chloride-hexane, 8.03 g