関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitrobenzene | HCID 7416 | — |
| 反応物 | N-Ethyloxindole | HCID 66135 | — |
| 反応物 | 2-Thiophenecarbonyl chloride | HCID 78928 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Ethyl-5-(2-thenoyl)oxindole | HCID 13770528 | 47.7% |
反応手順
To a mixture of 27.3 g. (19.9 mmoles) of 2-thenoyl chloride, 30 ml. of nitrobenzene and 32.95 g. of aluminum chloride was gradually added 10 g. (62 mmoles) of 1-ethyloxindole, and the resulting reaction mixture heated at 100° C. for 75 minutes. The reaction was cooled to room temperature and poured into 2 l. of ice and water. The product was extracted with methylene chloride and the dried extract concentrated to dryness, 11.05 g. The product was recrystallized from methylene chloride-hexane, 8.03 g. (47.7% yield)m, m.p. 158°-160° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04644005 |
|---|
| 出典データセット | uspto-grants-1987_02 |
|---|
| ORD ID | ord-5129419c816d4a35b034d0f56266c34c |
|---|
| 出典メモ | uspto-grants-1987_02 |
|---|
