6-(6-{[(1,1-Dimethylethoxy)carbonyl]amino}pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid → 6-(Oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid

HRID 2363747Notes

Reaction equation

HRID 2363747 reaction equation
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=2)[CH:11]=1.CC(C)(OC(NC1N=C(C2C=CC3N(C=C(C(O)=O)N=3)C=2)C=CC=1)=O)C>>[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 441249406-(6-{[(1,1-Dimethylethoxy)carbonyl]amino}pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acidHCID 44136337Ethyl 6-(oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylate

Product 1

HCID 441250796-(Oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acidYield 80%

Procedure

512 mg of ethyl 6-(oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylate are saponified under conditions similar to those described for the preparation of Intermediate 11 (step 11.3) to give 365 mg of 6-(oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid in the form of a white solid.

Sources & evidence

ORD record
ord-bca18da3ee2b41ef9abaa0328f08dc85
Source dataset
uspto-grants-2014_04
Patent number
US08691990B2

Reaction notes

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