HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(6-{[(1,1-Dimethylethoxy)carbonyl]amino}pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid → 6-(Oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(6-{[(1,1-Dimethylethoxy)carbonyl]amino}pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid | HCID 44124940 | — |
| Reactant | Ethyl 6-(oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylate | HCID 44136337 | — |
| Product | 6-(Oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid | HCID 44125079 | 80% |
Reaction Steps
512 mg of ethyl 6-(oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylate are saponified under conditions similar to those described for the preparation of Intermediate 11 (step 11.3) to give 365 mg of 6-(oxazol-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid in the form of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691990B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-bca18da3ee2b41ef9abaa0328f08dc85 |
| Source note | uspto-grants-2014_04 |