反应详情

Pantoprazole sodium (75 gms) as prepared according to Example-1 or Example-2 was dissolved in 375 ml of acetone at about 50-55° C., charcoal (5 gms) was added and the reaction mass was stirred for 15 minutes and clarified hot. The resulting clear filtrate was concentrated to approx. volume of 150 ml, ethyl acetate (400 ml) was added and distillation was continued until precipitation was observed in the reaction mass. The reaction mass was cooled to room temperature and water (4.2 ml) was added, the suspension was stirred for 1 hr. and later chilled and stirred at 0-5° C. for 1 hr. The product was the isolated by filtration and was dried at 40-45° C. under vacuum to give pantoprazole sodium sesquihydrate (68 gms.) having a moisture content of 6.5%.

1. concentrationThe resulting clear filtrate was concentrated to approx. volume of 150 ml, ethyl acetate (400 ml)
2. additionwas added
3. distillationdistillation
4. customwas continued until precipitation
5. additionwater (4.2 ml) was added
6. stirringthe suspension was stirred for 1 hr
7. temperatureand later chilled
8. stirringstirred at 0-5° C. for 1 hr
9. customisolated by filtration
10. customwas dried at 40-45° C. under vacuum