反应详情

A mixture of methyl 3-(ethylamino)-5-(pyridin-4-yl)thiophene-2-carboxylate (0.636 g, 2.42 mmol), sodium methoxide (0.393 g, 7.27 mmol), methanol (10 mL) and water (2.5 mL) was refluxed overnight. The mixture was cooled in an ice-bath and conc. HCl (0.600 mL, 7.27 mmol) was added to adjust the pH to 4. The resultant yellow precipitate was collected by filtration and washed with water and methanol to afford the title compound (0.415 g, 69%) as an orange solid:

1. temperaturewas refluxed overnight
2. temperatureThe mixture was cooled in an ice-bath
3. filtrationThe resultant yellow precipitate was collected by filtration
4. washwashed with water and methanol