反应详情

温度

70 °C

A mixture of methyl 3-[(1-methylethyl)amino]-5-(pyridin-4-yl)thiophene-2-carboxylate (0.250 g, 0.905 mmol) and 2 M sodium hydroxide (1.36 mL, 2.72 mmol) in methanol (5 mL) was heated at 70° C. for 3 h. Then, the reaction was cooled to room temperature and concentrated. The obtained residue was dissolved in water (5 mL) and acidified with 1 M HCl (2.7 mL) and 4 drops of acetic acid. The resulting yellow precipitate was collected by filtration, washed with water and dried to give the title compound (0.229 g, 96%) as a yellow solid:

1. temperatureThen, the reaction was cooled to room temperature
2. concentrationconcentrated
3. dissolutionThe obtained residue was dissolved in water (5 mL)
4. filtrationThe resulting yellow precipitate was collected by filtration
5. washwashed with water
6. customdried