Sodium Hydroxide → 3-[(1-Methylethyl)amino]-5-(pyridin-4-yl)thiophene-2-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 3-[(1-methylethyl)amino]-5-(pyridin-4-yl)thiophene-2-carboxylate (0.250 g, 0.905 mmol) and 2 M sodium hydroxide (1.36 mL, 2.72 mmol) in methanol (5 mL) was heated at 70° C. for 3 h. Then, the reaction was cooled to room temperature and concentrated. The obtained residue was dissolved in water (5 mL) and acidified with 1 M HCl (2.7 mL) and 4 drops of acetic acid. The resulting yellow precipitate was collected by filtration, washed with water and dried to give the title compound (0.229 g, 96%) as a yellow solid:

Provenance & Evidence