Hydrochloric Acid → 3-(methylamino)-5-(1H-pyrazol-4-yl)thiophene-2-carboxamide dihydrochloride

HRID 2364023Notes

Reaction equation

HRID 2364023 reaction equation
[CH3:1][N:2]1[C:7]2[CH:8]=[C:9]([C:11]3[CH:12]=[N:13][NH:14][CH:15]=3)[S:10][C:6]=2[C:5](=[O:16])[NH:4]C1(C)C.[ClH:19]>CO>[ClH:19].[ClH:19].[CH3:1][NH:2][C:7]1[CH:8]=[C:9]([C:11]2[CH:15]=[N:14][NH:13][CH:12]=2)[S:10][C:6]=1[C:5]([NH2:4])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 667433581,2,2-trimethyl-6-(1H-pyrazol-4-yl)-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one

Product 1

HCID 667434043-(methylamino)-5-(1H-pyrazol-4-yl)thiophene-2-carboxamide dihydrochlorideYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 1,2,2-trimethyl-6-(1H-pyrazol-4-yl)-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one (262 mg, 1.00 mmol), 1 M HCl (5 mL) and MeOH (5 mL) was stirred at 50° C. for 1 h. The mixture was concentrated under reduced pressure to afford the title compound (292 mg, 99%) as a pale yellow solid. This material was used for the next reaction without further purification.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0227be9669794d60aa2582eea9159518
Source dataset
uspto-grants-2014_04
Patent number
US08691828B2

Reaction notes

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