Benzaldehyde → HCID 5260199, compound

HRID 2364115Notes

Reaction equation

HRID 2364115 reaction equation
[C:1]1([P:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:9][CH2:10][NH2:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[CH:18](=[N:11][CH2:10][CH2:9][CH2:8][P:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 2806773-(Diphenylphosphino)-1-propylamine

Product 1

HCID 5260199HCID 5260199, compoundYield 96.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Under argon, a solution of 3-diphenylphosphino-propylamine (631.2 mg, 2.6 mmol) and benzaldehyde (278.1 mg, 2.6 mmol) in ethanol (15 mL) was heated at 65° C. (oil bath) for 4 h. Then, the solvent was removed in-vacuo to give the desired product (>98% by 1H-NMR) as a white solid (822.3 mg, 2.5 mmol, 96%).

Workup

  1. customThen, the solvent was removed in-vacuo

Sources & evidence

ORD record
ord-b7b81448a54d49bb80aea0a523f50275
Source dataset
uspto-grants-2014_04
Patent number
US08692022B2

Reaction notes

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