Benzaldehyde → HCID 59390147, compound

HRID 2364116Notes

Reaction equation

HRID 2364116 reaction equation
[CH2:1]([P:5]([CH2:10][CH:11]([CH3:13])[CH3:12])[CH2:6][CH2:7][CH2:8][NH2:9])[CH:2]([CH3:4])[CH3:3].[CH:14](=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)C>[CH:14](=[N:9][CH2:8][CH2:7][CH2:6][P:5]([CH2:10][CH:11]([CH3:13])[CH3:12])[CH2:1][CH:2]([CH3:3])[CH3:4])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 18935348HCID 18935348, compound

Product 1

HCID 59390147HCID 59390147, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Under argon, a solution of 3-diisobutylphosphino-propylamine (428.5 mg, 2.11 mmol) and benzaldehyde (226.9 mg, 2.14 mmol) in ethanol (15 mL) was heated at 65° C. (oil bath) for 4 h. Then, the solvent was removed in-vacuo to give the desired product (>98% by 1H-NMR) as a colourless liquid (614.1 mg, 2.1 mmol, quantitative).

Workup

  1. customThen, the solvent was removed in-vacuo

Sources & evidence

ORD record
ord-d6c568c8b245488b903dc64f9354dbd2
Source dataset
uspto-grants-2014_04
Patent number
US08692022B2

Reaction notes

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