反应详情

The compound of Example 1 (130 mg), 5N HCl (5 ml) and ethanol (9 ml) were heated under reflux for 3 h. After cooling, the reaction mixture was diluted with water and basified with dilute sodium hydroxide solution, extracted with ethyl acetate, and dried with anhydrous magnesium sulphate. Removal of drying agent and evaporation gave a red solid (130 mg). Recrystallisation from ethyl acetate-pentane gave the nitroamine (40 mg) as brick red crystals of m.p. 244°-245° C.

1. temperatureunder reflux for 3 h
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. dry with materialdried with anhydrous magnesium sulphate
5. customRemoval
6. customof drying
7. customagent and evaporation