3-Iodo-1-propanol → HCID 69481032, compound

Participants

Reaction Steps

In a similar manner to that described in example 316 step 1, from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (20 mg, 0.0584 mmol), lithium (bis-trimethylsilyl)amide (0.18 mL of a 1 M tetrahydrofuran solution, 0.18 mmol), and 3-iodo-1-propanol (0.03 mL, 0.350 mmol) was prepared ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(3-hydroxypropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (22 mg, 95% yield) as a yellow oil. The product was carried on without further purification. MS m/z 423 (M+23).

Provenance & Evidence