3-Amino-1,2-propanediol → HCID 69481015, compound

HRID 2364477Notes

Reaction equation

HRID 2364477 reaction equation
[F:1][C:2]1[CH:33]=[CH:32][C:5]([CH2:6][C:7]2[CH:16]=[C:15]3[C:10]([C:11]([OH:31])=[C:12]([C:26](OCC)=[O:27])[C:13](=[O:25])[N:14]3[CH2:17][CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][C:20]3=[O:24])=[N:9][CH:8]=2)=[CH:4][CH:3]=1.[NH2:34][CH2:35][CH:36]([OH:39])[CH2:37][OH:38]>>[OH:39][CH:36]([CH2:37][OH:38])[CH2:35][NH:34][C:26]([C:12]1[C:13](=[O:25])[N:14]([CH2:17][CH2:18][N:19]2[CH2:23][CH2:22][CH2:21][C:20]2=[O:24])[C:15]2[C:10]([C:11]=1[OH:31])=[N:9][CH:8]=[C:7]([CH2:6][C:5]1[CH:32]=[CH:33][C:2]([F:1])=[CH:3][CH:4]=1)[CH:16]=2)=[O:27]

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 58882907Ethyl 7-(4-fluorobenzyl)-4-hydroxy-2-oxo-1-[2-oxopyrrolidin-1-yl ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate

Product 1

HCID 69481015HCID 69481015, compound

Procedure

This compound was prepared from ethyl 7-(4-fluorobenzyl)-4-hydroxy-2-oxo-1-[2-(2-oxopyrrolidin-1-yl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 3-amino-1,2-propanediol using conditions similar to those employed in Example 563 to provide a white solid: ES+ MS: 499 (M+H+).

Workup

  1. customto provide a white solid

Sources & evidence

ORD record
ord-60b0a5dfa1634121a168addba0b20fbb
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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