Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 86612796, compound

HRID 2364505Notes

Reaction equation

HRID 2364505 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([OH:31])=[C:14]([C:24]([NH:26][CH2:27][CH2:28][O:29][CH3:30])=[O:25])[C:15](=[O:23])[N:16]3[CH2:19][C:20]([OH:22])=O)=[N:11][CH:10]=2)=[CH:4][CH:3]=1.Cl.[CH3:33][NH:34][O:35][CH3:36]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([OH:31])=[C:14]([C:24]([NH:26][CH2:27][CH2:28][O:29][CH3:30])=[O:25])[C:15](=[O:23])[N:16]3[CH2:19][C:20]([N:34]([CH3:33])[O:35][CH3:36])=[O:22])=[N:11][CH:10]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 59776534[7-[(4-fluorophenyl)methyl]-4-hydroxy-3-({[2-(methyloxy)ethyl]amino}carbonyl)-2-oxo-1,5-naphthyridin-1(2H)-yl]acetic acid

Product 1

HCID 86612796HCID 86612796, compound

Procedure

This compound was prepared from [7-[(4-fluorophenyl)methyl]-4-hydroxy-3-({[2-(methyloxy)ethyl]amino}carbonyl)-2-oxo-1,5-naphthyridine-1(2H)-yl]acetic acid and N,O-dimethylhydroxylamine hydrochloride employing methods similar to those described in Example 558 and was obtained as a white solid: 1H NMR (d6-DMSO) δ 10.17 (1H, br t, J=5 Hz), 8.53 (1H, s), 7.82 (1H, s), 7.32 (2H, t, J˜8 Hz), 7.12 (2H, t, J˜9 Hz), 5.19 (2H, s), 4.12 (2H, s), 3.83 (3H, s), 3.53-3.48 (4H, m), 3.26 (3H, s), 3.12 (3H, s); AP+ MS: 473 (M+H+, 100).

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-f1403a263a6144c9a1fe6f35eb1f3bc0
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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