6-Chlorohexanoyl chloride → HCID 86612801, compound

HRID 2364555Notes

Reaction equation

HRID 2364555 reaction equation
[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[CH2:5][CH2:6][NH2:7])[CH3:2].[Cl:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17](Cl)=[O:18]>>[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[CH2:5][CH2:6][NH:7][C:17](=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][Cl:11])[CH3:2]

Participants

3

Reactant 2

HCID 880146-Chlorohexanoyl chlorideHCID 5210291-Amino-3,3-diethoxypropane

Product 1

HCID 86612801HCID 86612801, compound

Procedure

This compound was prepared from [3,3-bis(ethyloxy)propyl]amine and 6-chlorohexanoyl chloride using methods similar to Example 669: step 1 to provide a yellow viscous oil: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.10 (t, J=7.09 Hz, 6 H), 1.28-1.40 (m, 2 H), 1.44-1.56 (m, 2 H), 1.59-1.75 (m, 4 H), 2.04 (t, J=7.23 Hz, 2 H), 3.01-3.09 (m, 2 H), 3.41 (dq, J=9.55, 7.07 Hz, 2 H), 3.50-3.64 (m, 4 H), 4.48 (t, J=5.69 Hz, 1 H), 7.74 (t, J=5.33 Hz, 1 H); ES+ MS: 302 (M+Na+).

Workup

  1. customto provide a yellow viscous oil

Sources & evidence

ORD record
ord-ba5c4a4aec4e4f7cac15b9778ec3ad21
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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