Hydrochloric Acid → HCID 178440993, compound

HRID 2364806Notes

Reaction equation

HRID 2364806 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]3[N:28]([C:29]4[CH:34]=[CH:33][C:32]([C:35]([CH3:38])([CH3:37])[CH3:36])=[CH:31][CH:30]=4)[CH:27]([C:39]4[CH:44]=[CH:43][C:42]([NH:45][C:46]([C@H:48]5[CH2:52][CH2:51][CH2:50][N:49]5C(OC(C)(C)C)=O)=[O:47])=[CH:41][CH:40]=4)[CH2:26][CH2:25]3)=[CH:20][CH:19]=2)[N:17]=1)=O)(C)(C)C.[ClH:60]>O1CCOCC1>[ClH:60].[C:35]([C:32]1[CH:31]=[CH:30][C:29]([N:28]2[CH:24]([C:21]3[CH:20]=[CH:19][C:18]([C:16]4[N:17]=[C:13]([C@@H:9]5[CH2:10][CH2:11][CH2:12][NH:8]5)[NH:14][CH:15]=4)=[CH:23][CH:22]=3)[CH2:25][CH2:26][CH:27]2[C:39]2[CH:40]=[CH:41][C:42]([NH:45][C:46]([C@H:48]3[CH2:52][CH2:51][CH2:50][NH:49]3)=[O:47])=[CH:43][CH:44]=2)=[CH:34][CH:33]=1)([CH3:38])([CH3:36])[CH3:37]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451942HCID 178451942, compound

Product 1

HCID 178440993HCID 178440993, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 40E (610 mg, 0.76 mmol), in 2M hydrochloric acid in dioxane solution (10 mL) was reacted according to the procedure in Example 39I to provide the title compound (495 mg) as a hydrochloride salt and a mixture of stereoisomers.

Sources & evidence

ORD record
ord-17e3abb53b1042a59d100d71c6115faf
Source dataset
uspto-grants-2014_04
Patent number
US08691938B2

Reaction notes

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