HCID 47283403, compound → HCID 67236906, compound

HRID 2364840Notes

Reaction equation

HRID 2364840 reaction equation
[CH3:1][O:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][C:12]=2[F:20])[CH2:7][CH2:6]1)=[O:4]>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3]([N:5]1[CH2:6][CH2:7][N:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=2[F:20])[CH2:9][CH2:10]1)=[O:4]

Participants

4

Reactant 1

HCID 47283403HCID 47283403, compound

Product 1

HCID 67236906HCID 67236906, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of Example 119B (3.0 g, 10.59 mmol) in EtOAc (40 mL) was added 10% palladium on carbon (300 mg) and the solution was stirred under a balloon of H2 gas for 1.5 h. The solution was filtered through Celite, the catalyst washed with EtOAc, and the filtrate concentrated in vacuo to give the title compound (2.68 g, 10.59 mmol, 100%).

Workup

  1. filtrationThe solution was filtered through Celite
  2. washthe catalyst washed with EtOAc
  3. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-d054182862b84964a92e38218eed3f32
Source dataset
uspto-grants-2014_04
Patent number
US08691938B2

Reaction notes

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