反应详情

To a solution of the product from Example 179A (10.0 g, 27.6 mmol) in EtOH (220 mL) was added sodium borohydride (2.190 g, 57.9 mmol) in several portions over 1 h. The resulting mixture was stirred at rt for 1 h, filtered through celite, and concentrated in vacuo. The residue was dissolved in EtOAc and washed by 1N aq. HCl. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo to give the title compound (9.29 g, 92%)

1. filtrationfiltered through celite
2. concentrationconcentrated in vacuo
3. dissolutionThe residue was dissolved in EtOAc
4. washwashed by 1N aq. HCl
5. dry with materialThe organic layer was dried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo