(Piperidine-1-yl)-acetic acid-benzylester → Piperidin-1-yl-acetic acid

HRID 2364932Notes

Reaction equation

HRID 2364932 reaction equation
C([O:8][C:9](=[O:17])[CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:11]1([CH2:10][C:9]([OH:17])=[O:8])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 11379293(Piperidine-1-yl)-acetic acid-benzylester

Product 1

HCID 201097Piperidin-1-yl-acetic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10.4 g (44 mMol) (piperidine-1-yl)-acetic acid-benzylester 9 was stirred with 0.25 g Pd/C (5%) in 100 ml Methanol at RT. Under normal pressure, the reaction mixture was reduced (hydrated) with H2. After having removed the catalyst, the solution was evaporated and the residue was resuspended in EtOAc and filtered off.

Workup

  1. customAfter having removed the catalyst
  2. customthe solution was evaporated
  3. filtrationfiltered off

Sources & evidence

ORD record
ord-3c06d4dd3ff941a0b0af65238a7c5a8d
Source dataset
uspto-grants-2014_04
Patent number
US08697604B2

Reaction notes

Loading…