HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → Trifluoro-methanesulfonic acid 3-chloro-1-(3-methyl-butyl)-2-oxo-1,2-dihydro-pyridin-4-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 4-Benzyloxy-2(1H)-pyridone | HCID 3607724 | — |
| Reactant | Trifluoromethanesulfonic acid 1-butyl-3-chloro-2-oxo-1,2-dihydropyridin-4-yl ester | HCID 25221428 | — |
| Reactant | 1-butyl-4-hydroxy-1H-pyridine-2-one | HCID 59497076 | — |
| Reactant | 1-(Cyclopropylmethyl)-4-hydroxypyridin-2(1H)-one | HCID 59497098 | — |
| Product | Trifluoro-methanesulfonic acid 3-chloro-1-(3-methyl-butyl)-2-oxo-1,2-dihydro-pyridin-4-yl ester | HCID 58505314 | — |
Reaction Steps
Intermediate D6 was prepared following the same procedure implemented for the synthesis of D4, using as starting material 1-cyclopropylmethyl-4-hydroxy-1H-pyridin-2-one which was prepared by the same method used for the synthesis of intermediate D2, by reaction of 4-benzyloxy-1H-pyridin-2-one with cyclopropylmethyl-bromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697689B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-5bb9270dbbe74146a9f7dcbc1bbe5f50 |
| Source note | uspto-grants-2014_04 |