HRID236501

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8206

Hexadecanoyl chloride

C16H31ClO

结构：CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1

HCID54081958

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCC(=O)N[C@H](C(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)C(C)C

HCID53989800

未命名化合物

收率 63.4%

PROCEDURE

实验过程

Starting from dibenzyl N-(N-tert-butoxycarbonyl-L-valyl)-L-glutamate (1 g) and hexadecanoyl chloride (620 mg), dibenzyl N-(N-hexadecanoyl-L-valyl)-L-glutamate (800 mg) was obtained as crystals according to a similar manner to that of Example 24.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9536b881da8e425a9b09543e05f20054
来源数据集: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04643990
来源说明: uspto-grants-1987_02

反应 SMILES

C(OC([NH:8][C@H:9]([C:13]([NH:15][C@H:16]([C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:17][CH2:18][C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20])=[O:14])[CH:10]([CH3:12])[CH3:11])=O)(C)(C)C.[C:39](Cl)(=[O:55])[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH3:54]>>[C:39]([NH:8][C@H:9]([C:13]([NH:15][C@H:16]([C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:17][CH2:18][C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20])=[O:14])[CH:10]([CH3:11])[CH3:12])(=[O:55])[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH3:54]