HCID 59625953, compound → HCID 59625849, compound

HRID 2365294Notes

Reaction equation

HRID 2365294 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([Cl:10])=[C:8]([C:11]([N:13]3[CH2:16][CH:15]([N:17]4[CH2:22][CH2:21][N:20](C(=O)C(F)(F)F)[CH2:19][CH2:18]4)[CH2:14]3)=[O:12])[S:7][C:6]=2[CH:29]=1>CCN(CC)CC.CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([Cl:10])=[C:8]([C:11]([N:13]3[CH2:16][CH:15]([N:17]4[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)[CH2:14]3)=[O:12])[S:7][C:6]=2[CH:29]=1

Participants

4

Reactant 1

HCID 59625953HCID 59625953, compound

Product 1

HCID 59625849HCID 59625849, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8471TriethylamineSolvent

Procedure

A solution of compound 11b (0.3 g, 0.59 mmol) in Et3N (1 mL) and MeOH (9 mL) was stirred at room temperature for 3 days. It was then concentrated to give compound 11c, which was used in the next reaction without further purification.

Workup

  1. concentrationIt was then concentrated

Sources & evidence

ORD record
ord-4ebe8bfad94e4d958b23e1df8eb2733f
Source dataset
uspto-grants-2014_04
Patent number
US08697684B2

Reaction notes

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